physician photo

Julie A. Margenthaler, MD, FACS

  • Professor of Surgery

Medical School

Southern Illinois University School of Medicine, 1997

Post Doctoral Education

General Surgery Residency (PGY-1, 2): Saint Louis University Hospitals, 1997-99

Postdoctoral Research Fellowship: Washington University School of Medicine, 1999-2002

General Surgery Residency (PGY-3-5): Washington University School of Medicine, 2002-2005

Breast Disease Fellowship: Washington University, 2005-2006

Board Certifications

Board certified -- American Board of Surgery

Honors and Awards

James Ewing Foundation grant, Society of Surgical Oncology (2006-2007)

Eugene M. Bricker Teaching Award (2005)

SUS/Ethicon Research Award (2000-2002)

NRSA/NIH Fellowship (2000-2002)

ALF Postdoctoral Fellowship Award (2000-2001)

Resident Teaching Award, 2004

Clinical Interests

Breast cancer
Breast cancer in young women (<40 years old)
Patients with high risk factors for breast cancer
Familial breast cancer
Breast reconstruction liaison
Sentinel lymph node biopsy

Research Interests

Susan G. Komen Breast Cancer Foundation STEP Grant, 2007-2008. Project: Reducing delays in cancer diagnosis in the St. Louis public safety net system.

James Ewing Foundation of the Society of Surgical Oncology, 2006-2007. Project: Minimally invasive staging of the axilla in breast cancer.

Longer Life Foundation, 2006-007. Project: Minimally invasive staging of the axilla in breast cancer using RT-PCR.

Clinical Trials
(Principal Investigator only)

#05-0956. “Outcomes of Patients with Primary Breast Sarcoma.” (closed)

#05-0957, “Effect of Surgical Resection of Primary Breast Cancers in Patients with Stage IV Disease at the Time of Diagnosis.” (closed)

#06-0351, “Treatment and Outcome of Patients with Intracystic Papillary Carcinoma of the Breast.” (closed)

#06-0425, “Recurrence of Breast Cancer after Skin Sparing Mastectomy.” (closed)

#06-0530, “Minimally Invasive Staging of the Axilla in Breast Cancer: A Pilot Study to Assess the Feasibility and Sensitivity of Real-Time PCR, Axillary Ultrasound, and Fine Needle Aspiration Biopsy.”

#06-0949, “Characteristics and Outcomes of Patients with Metastatic Tumors to the Breast.” (closed)

#07-0302, “Risk Factors for Benign Breast Abscesses.” (closed)

#07-0622, “Reducing Delays in Cancer Diagnosis in the St. Louis Public Safety Net System.”

#07-0623 “Evaluating the Sensitivity and Specificity of Axillary Ultrasound and Fine Needle Aspiration Biopsy in Staging the Axilla of Patients with Early Stage Breast Cancer.”

#07-0699, “Is Sentinel Lymph Node Staging Accurate in Patients with Multicentric Breast Cancer?”

#07-0700, “Predictors of Developing Contralateral Breast Cancer in Young Women (<40 Years Old).”

#07-0973, “Examining Factors that Contribute to the Diagnosis of Late-Stage Breast Cancer (Stage III and IV) at a Publicly Funded Community Health Center.”
Staging of the axilla in breast cancer patients
Breast cancer vaccine development
Breast cancer genetics

Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Center for Advanced Medicine
Joanne Knight Breast Health Center
4921 Parkview Place, Suite F, Floor 5
St. Louis, MO 63110
(314) 362-7534

Contact Information

Section of Endocrine and Oncologic Surgery
Department of Surgery
Washington University School of Medicine
660 S. Euclid
Box 8109
St. Louis, MO 63110

Selected Publications

Margenthaler JA, Klimberg VS. Margin status following partial mastectomy: one size does not fit all! Oncology (Williston Park). 2011 Sep;25(10):899, 903.

Fisher CS, Klimberg VS, Khan S, Gao F, Margenthaler JA. Margin index is not a reliable tool for predicting residual disease after breast-conserving surgery for DCIS. Ann Surg Oncol. 2011 Oct;18(11):3155-9.

Fisher CS, Mushawah FA, Cyr AE, Gao F, Margenthaler JA. Ultrasound-guided lumpectomy for palpable breast cancers. Ann Surg Oncol. 2011 Oct;18(11):3198-203.

Fisher CS, Margenthaler JA. A look into the ductoscope: its role in pathologic nipple discharge. Ann Surg Oncol. 2011 Oct;18(11):3187-91.

Cyr AE, Margenthaler JA, Conway J, Rastelli AL, Davila RM, Gao F, Dietz JR. Correlation of ductal lavage cytology with ductoscopy-directed duct excision histology in women at high risk for developing breast cancer: a prospective, single-institution trial. Ann Surg Oncol. 2011 Oct;18(11):3192-7.

Fisher CS, Ma CX, Gillanders WE, Aft RL, Eberlein TJ, Gao F, Margenthaler JA. Neoadjuvant Chemotherapy Is Associated with Improved Survival Compared with Adjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer Only after Complete Pathologic Response. Ann Surg Oncol. 2011 Jul 2.

Fisher CS, Wachtel MS, Margenthaler JA. Outcomes for Patients who Develop Both Breast and Colorectal Cancer. Ann Surg Oncol. 2011 Jun 24. [Epub ahead of print]

Al Mushawah F, Rastelli A, Pluard T, Margenthaler JA. Metastatic Invasive Breast Cancer Recurrence Following Curative-Intent Therapy for Ductal Carcinoma In Situ. J Surg Res. 2011 May 23. [Epub ahead of print]

Ellis MJ, Suman VJ, Hoog J, Lin L, Snider J, Prat A, Parker JS, Luo J, DeSchryver K, Allred DC, Esserman LJ, Unzeitig GW, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Watson MA, Leitch M, Hunt K, Olson JA. Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype--ACOSOG Z1031. J Clin Oncol. 2011 Jun 10;29(17):2342-9. Epub 2011 May 9.

Wilkinson J, Appleton CM, Margenthaler JA. Utility of breast MRI for evaluation of residual disease following excisional biopsy. J Surg Res. 2011 Oct;170(2):233-9. Epub 2011 Apr 13.

Gnerlich JL, Deshpande AD, Jeffe DB, Seelam S, Kimbuende E, Margenthaler JA. Poorer survival outcomes for male breast cancer compared with female breast cancer may be attributable to in-stage migration. Ann Surg Oncol. 2011 Jul;18(7):1837-44.

Margenthaler JA. The Cancer Genome: Translating Sequences into Patient Therapeutics. J Surg Res. 2011 Mar 1.

Margenthaler JA. Optimizing conservative breast surgery. J Surg Oncol. 2011 Mar 15;103(4):306-12.

Cyr A, Gillanders WE, Aft RL, Eberlein TJ, Margenthaler JA. Breast cancer in elderly women (= 80 years): variation in standard of care? J Surg Oncol. 2011 Mar 1;103(3):201-6.

Margenthaler JA. Invasive Lobular Breast Cancer: Does Grade Matter? J Surg Res. 2010 Sep 8. [Epub ahead of print]

Pub Med for Julie A. Margenthaler, M.D.


Margenthaler J and Klingensmith ME. Stomach. In: Klingensmith ME (ed.). Washington University Manual of Surgery. 4th Edition. Philadelphia: Lippincott Williams & Wilkins; 2005.

Margenthaler J, Schuerer D, Whinney R. Acute cholecystitis. In: Clinical Evidence. 11th edition. BMJ Publishing Group; 2004:524-532.

Margenthaler J, Hermann VM, Hickey MS. Surgical Metabolism and Nutrition. In: Way LW, Doherty GM (eds.). Current Surgical Diagnosis & Treatment. 11th edition. Chapter 11, pp. 156-190.

Margenthaler J, Hermann VM. Nutrition. In: Doherty GM (ed.). Washington University Manual of Surgery. 3rd Edition. Philadelphia: Lippincott Williams & Wilkins; 2002. Chapter 2, pp. 9-26.